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Type: Artigo de periódico
Title: Prognostic Factors for Hepatocellular Carcinoma Recurrence: Experience With 83 Liver Transplantation Patients
Author: Ataide, EC
Boin, IFSF
Almeida, JRS
Seva-Pereira, T
Stucchi, RSB
Cardoso, AR
Caruy, CAA
Escanhoela, CAF
Abstract: Introduction. Orthotopic liver transplantation (OLT) is a rational therapeutic option for early-stage hepatocellular carcinoma (HCC) providing a potential cure and improving survival. Methods. This retrospective study of a longitudinal cohort used an electronic database collected prospectively from September 1997 to May 2010. The variables were gender, age (years), and alpha-fetoprotein (AFP) level (ng/mL). In explanted livers we observed: microvascular or macrovascular invasion, number of nodules and their largest size, Edmondson-Steiner histological differentiation, incidental tumor transarterial chemoembolization (TACE), Milan criteria, and previous down-staging. Results. Five of 83 (6.0%) subjects including 68 (82%) males with a mean time to diagnosis of 9 months experienced tumor relapses. Mean patient age at HCC recurrence was 55.3 years for male and 44.6 years for female subjects. Vascular invasion was detected in 17/83 (20.5%) subjects, namely 2% of macrovascular invasion, and 52.5% with expanded Milan criteria due to an increased number and size of nodules in the explanted livers. An incidental tumor was observed in 29.5% of cases. Preoperative TACE treatment was performed in 13 (15.6%) patients. None of the patients who had a HCC recurrence had undergone TACE. APP level at the time of recurrence was around 1,900 ng/mL. The predictive factor for mortality was nodule size (P = .04; hazard ratio = 0.0269; confidence interval [CI], 95% 0.0094-0.299). Conclusion. Patients with relapses showed the worst survival and tumor size was a predictive factor for recurrence.
Country: EUA
Editor: Elsevier Science Inc
Citation: Transplantation Proceedings. Elsevier Science Inc, v. 43, n. 4, n. 1362, n. 1364, 2011.
Rights: fechado
Identifier DOI: 10.1016/j.transproceed.2011.02.032
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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