Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/703
Type: Artigo de periódico
Title: Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis
Author: PEIXOTO, Fabio
CAMARGOS, Aroldo
DUARTE, Geraldo
LINHARES, Iara
BAHAMONDES, Luis
PETRACCO, Alvaro
Abstract: Objective: To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis. Methods: Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment. Results: Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated. Conclusion: Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis. (c) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Subject: bacterial vaginosis
metronidazole
miconazole
trichomonal vaginitis
vulvovaginal candidiasis
Country: Irlanda
Editor: ELSEVIER IRELAND LTD
Rights: fechado
Identifier DOI: 10.1016/j.ijgo.2008.04.014
Address: http://dx.doi.org/10.1016/j.ijgo.2008.04.014
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Date Issue: 2008
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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