Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/70255
Type: Artigo de periódico
Title: Prevention of hypertension attenuates albuminuria and renal expression of fibronectin in diabetic spontaneously hypertensive rats
Author: Pavan, MV
Ghini, B
Castro, M
de Faria, JBL
Abstract: Background/ Aim: The aim of this study was to evaluate the effect of preventing hypertension on renal disease in a model of genetic hypertension and diabetes. Methods: Four- week- old spontaneously hypertensive rats ( SHR) with streptozotocin- induced diabetes were randomized for no treatment, or for treatment with captopril, losartan or triple therapy ( hydrochlorothiazide, reserpine and hydralazine) for 16 weeks. Results: Increase in systolic blood pressure was equally prevented by captopril ( 128 +/- 3 mm Hg), losartan ( 128 +/- 2) and triple therapy ( 129 +/- 2, p < 0.0001). Albuminuria was similarly reduced by captopril ( 499 ( 404 - 659)), losartan ( 622 ( 470 - 976)) and triple therapy ( 479 ( 362 - 600) &mu;g/ 24 h ( p < 0.0001)). Renal fibronectin expression increased in diabetic SHR ( 125 +/- 13 densitometric unit) as compared to the controls ( 51 +/- 9, p < 0.0001), and decreased ( p < 0.0001 vs. diabetic SHR) with captopril ( 32 +/- 8), losartan ( 27 +/- 4) and triple therapy ( 35 +/- 6). Conclusion: The prevention of hypertension in diabetic SHR by captopril, losartan or triple therapy was equally efficacious in impeding increase of albuminuria and the expression of renal fibronectin. Under these conditions, tight blood pressure control was the main determinant in attenuating nephropathy. Copyright (C) 2003 S. Karger AG, Basel.
Subject: angiotensin antagonist
angiotensin-converting enzyme
diabetes mellitus
fibronectin
hypertension, genetic
rats, inbred SHR
renin-angiotensin system
Country: Suíça
Editor: Karger
Rights: fechado
Identifier DOI: 10.1159/000074454
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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