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Type: Artigo de periódico
Title: Prevalence of the prothrombin gene variant 20210 G -> A among patients with myocardial infarction
Author: Arruda, VR
Siquiera, LH
Chiaparini, LC
Coelho, OR
Mansur, AP
Ramires, A
Annichino-Bizzacchi, JM
Abstract: Objective: The aim of this study was to determine the prevalence of the prothrombin variant allele 20210A among survivors of myocardial infarction Background: The prothrombin gene variant has been identified as a novel genetic risk factor for venous thrombosis. However, the risk of developing arterial thrombosis as a result of the presence of this mutated allele is unknown. Methods: The G --> A transition at position 20210 of the 3'-untranslated region was determined in 220 survivors of myocardial infarction and in 295 individuals from the general population. Results: The prevalence of heterozygotes for the prothrombin mutated allele was 3% among patients with myocardial infarction and 0.7% in the general population (P = 0.03). No age-related difference in the prevalence of the mutated allele was observed. However, for individuals over 45 years old the prevalence among females was higher than among males (5% vs. 0%). Conclusion: These data suggest that being heterozygote for the allele variant 20210A of the prothrombin gene could be a genetic risk factor for developing myocardial infarction. (C) 1998 Elsevier Science B.V.
Subject: myocardial infarction
risk factors
DNA polymorphism
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/S0008-6363(97)00211-3
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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