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Type: Artigo de periódico
Title: Preparation of Polymeric Nanoparticles by Polymerization of Monomers - Part I
Author: Souto, EB
Severino, P
Santana, MHA
Abstract: Polymeric nanoparticles obtained from synthetic polymers such as copolymers of methacrylic acid, acrylic esters or metacrylics, have been widely used in pharmaceuticals for encapsulation of drugs. These nanoparticles have the advantages of drug protection, controlled release, improved bioavailability and lower toxicity, resulting in greater comfort to patients and compliance to the treatment. The production of nanoparticles (nanospheres and nanocapsules) by polymerization of monomers is reviewed and discussed in this article, highlighting the technological parameters that affect the physicochemical characteristics of nanoparticles, e.g. drug solubility, phase volume, pH of polymerization, molecular weight and monomer concentration, and the nature and concentration of the surfactant.
Subject: Nanocapsules
polymerization of monomers
Country: Brasil
Editor: Assoc Brasil Polimeros
Citation: Polimeros-ciencia E Tecnologia. Assoc Brasil Polimeros, v. 22, n. 1, n. 96, n. 100, 2012.
Rights: aberto
Identifier DOI: 10.1590/S0104-14282012005000006
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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