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Type: Artigo de periódico
Title: Preparation and evaluation of inclusion complexes of commercial sunscreens in cyclodextrins and montmorillonites: Performance and substantivity studies
Author: Coelho, GLN
Dornelas, CB
Soares, KCC
dos Santos, EP
Vergnanini, AL
dos Santos, TC
Rodrigues, CR
Castro, HC
Dias, LRS
Cabral, LM
Abstract: Herein we describe inclusion complexes of commercial sun-screens in cyclodextrins and montmorillonites to generate new sunscreen derivatives with optimized functional properties such as water resistance and skin adherence. Four cyclodextrins (alpha-, beta-, and gamma-cyclodextrin, and beta-dimethyl cyclodextrin) and two mont-morillonites (sodium and alkylammonium) were investigated for encapsulating some commercial sunscreens. Our results reveal a good yield and inclusion products with functional properties obtained by using kneading technique on Eusolex (R) 2292 and Eusolexo 6007 in beta-cyclodextrin and solubilization method on Eusolex (R) 6007 and NeoHeliopan (R) MA in montmorillonite. In addition, molecular modeling studies indicated flexibility as important for the intercalation of the host molecule.
Subject: coprecipitation
kneading techniques
Country: EUA
Editor: Taylor & Francis Inc
Citation: Drug Development And Industrial Pharmacy. Taylor & Francis Inc, v. 34, n. 5, n. 536, n. 546, 2008.
Rights: fechado
Identifier DOI: 10.1080/03639040701831769
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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