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Type: Artigo de periódico
Title: Preparation and characterization of poly(e-caprolactone) nanospheres containing the local anesthetic lidocaine
Author: Campos, EVR
de Melo, NFS
Guilherme, VA
de Paula, E
Rosa, AH
de Araujo, DR
Fraceto, LF
Abstract: The objective of this work was to develop a modified release system for the local anesthetic lidocaine (LDC), using poly(e-caprolactone) (PCL) nanospheres (NSs), to improve the pharmacological properties of the drug when administered by the infiltration route. In vitro experiments were used to characterize the system and investigate the release mechanism. The NSs presented a polydispersion index of 0.072, an average diameter of 449.6?nm, a zeta potential of -20.1?mV, and an association efficiency of 93.3%. The release profiles showed that the release of associated LDC was slower than that of the free drug. Atomic force microscopy analyses showed that the spherical structure of the particles was preserved as a function of time, as well as after the release experiments. Cytotoxicity and pharmacological tests confirmed that association with the NSs reduced the toxicity of LDC, and prolonged its anesthetic action. This new formulation could potentially be used in applications requiring gradual anesthetic release, especially dental procedures. (c) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:215226, 2013
Subject: lidocaine
polymeric drug carrier
drug release
anesthetic activity
controlled release
Country: EUA
Editor: Wiley-blackwell
Citation: Journal Of Pharmaceutical Sciences. Wiley-blackwell, v. 102, n. 1, n. 215, n. 226, 2013.
Rights: fechado
Identifier DOI: 10.1002/jps.23350
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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