Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Impregnation of implantable polypropylene mesh with S-nitrosoglutathione-loaded poly(vinyl alcohol)
Author: Prudente, A
Riccetto, CLZ
Simoes, MMDG
Pires, BM
de Oliveira, MG
Abstract: Clinical complications of implantable polypropylene (PP) meshes used to repair urinary incontinence and vaginal prolapse may be associated with their low surface energy and consequent poor tissue integration. For improving tissue integration, we impregnated monofilament PP meshes with physically crosslinked poly(vinyl alcohol) (PVA), resulting in PVA deposits tightly attached inside the knot spaces of the PP knit. While preserving the mesh porosity, the PVA deposits acted as an array of hydrophilic regions leading to a great increase in the overall mesh wettability, reflected by a contact angle decrease from 111 to ca. 66 degrees. The PVA deposits were also used as reservoirs for the local release of S-nitrosoglutathione (GSNO), a nitric oxide (NO) donor. Plain and impregnated PP meshes (1.0 cm x 1.0 cm) were implanted in the subcutaneous tissue of 21 adult female Wistar rats. Histological analysis of the abdominal wall 21 days after the surgeries revealed lower edema and greater angiogenesis while a marked decrement of NOx concentration in the tissue surrounding the impregnated meshes was observed after 2 days. These results indicate that PVA and PVA/GSNO impregnation might be a new strategy for decreasing the frequency of mesh extrusion after PP mesh implants. (C) 2013 Elsevier B.V. All rights reserved.
Subject: Polypropylene mesh
Poly(vinyl alcohol)
Tissue integration
Nitric oxide
Country: Holanda
Editor: Elsevier Science Bv
Citation: Colloids And Surfaces B-biointerfaces. Elsevier Science Bv, v. 108, n. 178, n. 184, 2013.
Rights: fechado
Identifier DOI: 10.1016/j.colsurfb.2013.02.018
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.