Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/70025
Type: Artigo
Title: Impaired humoral response to vaccines among HIV-exposed uninfected infants
Title Alternative: 
Author: Mazzola, T.N.
Abramczuk, B.M.
Moreno, Y.M.F.
Zorzeto, T.Q.
Morcillo, A.M.
Silva, M.T.N.
Blotta, M.H.
Wolf, P.S.
Quintilio, W.
Vilela, M.M.D.
Abstract: Little is known about the vaccine protective response for infants born from HIV-infected mothers. We evaluated the antibody response to hepatitis B, tetanus, and diphtheria vaccine in vertically HIV-exposed uninfected infants and compared them to those of control infants not exposed to the virus. The quantitative determination of specific neutralizing antibodies against hepatitis B, diphtheria, and tetanus were performed blindly on serum samples. The results showed that 6.7% of the HIV-exposed uninfected individuals were nonresponders to hepatitis B vaccine (anti-HBs titer, <10 mIU/ml), and 64.4% were very good responders (anti-HBs titer, >= 1,000 mIU/ml), whereas only 3.6% of the nonexposed infants were nonresponders (chi(2) = 10.93; 1 df). The HIV-exposed uninfected infants showed protective titers for diphtheria and tetanus but lower geometric mean anti-tetanus titers compared to those of the HIV-unexposed infants. Our data point to the necessity of evaluating vaccine immune responses in these children and reinforced that alterations in lymphocyte numbers and functions reported for newborns from HIV-infected mothers interfere with the vaccine response
metadata.dc.description.abstractalternative: 
Subject: Hepatite B
HIV
Formação de anticorpos
Country: Estados Unidos
Editor: American Society for Microbiology
Citation: Clinical And Vaccine Immunology. Amer Soc Microbiology, v. 18, n. 9, n. 1406, n. 1409, 2011.
Rights: Fechado
Identifier DOI: 10.1128/CVI.05065-11
Address: http://cvi.asm.org/content/18/9/1406.long
Date Issue: 2011
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
21775515.pdf131.72 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.