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Type: Artigo de periódico
Title: Impact of Seasonality on the Prevalence of Dyslipidemia: A Large Population Study
Author: Moura, FA
Dutra-Rodrigues, MS
Cassol, AS
Parra, ES
Zago, VHS
Panzoldo, NB
Alexandre, F
Vieira, IC
Vendrame, F
Virginio, VW
Castanho, VS
Danelon, MRG
Nunes, VS
Leanca, CC
Saraiva, FK
Coelho, OR
Nakandakare, E
Quintao, ECR
de Faria, EC
Sposito, AC
Abstract: Assessment of lipid profile parameters has been considered a cornerstone in classifying individuals and populations at risk for cardiovascular disease. Recently, however, preliminary data have raised the possibility of seasonal variations in these parameters, which may cause under- or overestimation. Biological rhythms and seasonal variation of lipid profile was investigated in 227 359 consecutive individuals who underwent health checkups in primary care centers between 2008 and 2010. Plasma low-density lipoprotein cholesterol (LDL-C) >130 mg/dL was 8% more prevalent during winter than summer, with a larger difference among women and middle-aged adults (p<0.001). High-density lipoprotein cholesterol (HDL-C) <40 mg/dL and triglycerides (TG) >150 mg/dL were respectively 9% and 5% more prevalent during the summer (p<0.001). Variation amplitude was 3.4 +/- 0.3 mg/dL for HDL-C (p = 0.005), 7 +/- 2 mg/dL for LDL-C (p = 0.047), and 12 +/- 9 mg/dL for TG (p = 0.058). Based on a large population sample, this study confirms the existence of biological rhythms and seasonal variation in lipid profile. This finding must be particularly accounted for in cross-sectional analyses of relative risk, prevalence, or the rate of goal achievement for lipid parameters.
Subject: Lipid profile
primary prevention
Country: Inglaterra
Editor: Informa Healthcare
Citation: Chronobiology International. Informa Healthcare, v. 30, n. 8, n. 1011, n. 1015, 2013.
Rights: fechado
Identifier DOI: 10.3109/07420528.2013.793698
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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