Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/700
Type: Artigo de periódico
Title: eNOS haplotypes affect the responsiveness to antihypertensive therapy in preeclampsia but not in gestational hypertension
Author: SANDRIM, V. C.
PALEI, A. C. T.
LUIZON, M. R.
IZIDORO-TOLEDO, T. C.
CAVALLI, R. C.
TANUS-SANTOS, J. E.
Abstract: Variations of the endothelial nitric oxide synthase (eNOS) gene have been associated with hypertensive disorders of pregnancy. We examined whether eNOS polymorphisms affect the therapeutic responses of women with gestational hypertension (GH) or preeclampsia (PE). We studied 304 hypertensive pregnant women (152 GH and 152 PE), who were stratified according to clinical and laboratorial parameters of therapeutic responsiveness. We compared the frequencies of three eNOS genetic polymorphisms (T-786C, Glu298Asp and b/a intron 4) in responsive and nonresponsive PE and GH patients. We found no significant differences in genotype or allele distributions when responsive and nonresponsive groups were compared (both PE or GH; all P > 0.05). However, the eNOS haplotype distribution differed in PE (but not in GH)-responsive and -nonresponsive groups (P = 0.0003). The `C-Glu-a` and `T-Asp-a` hapotypes were associated with responsiveness and nonresponsiveness to therapy, respectively (both P < 0.001), thus suggesting that eNOS haplotypes affect the responsiveness to antihypertensive therapy in PE. The Pharmacogenomics Journal (2010) 10, 40-45; doi: 10.1038/tpj.2009.38; published online 25 August 2009
Subject: antihypertensives
eNOS
gestational hypertension
pharmacogenetics
polymorphisms
preeclampsia
Country: Inglaterra
Editor: NATURE PUBLISHING GROUP
Rights: fechado
Identifier DOI: 10.1038/tpj.2009.38
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000273876100005&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://dx.doi.org/10.1038/tpj.2009.38
Date Issue: 2010
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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