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Type: Artigo de periódico
Title: Immunophenotypic characterization and distribution of dendritic cells in odontogenic cystic lesions
Author: Matos, FTC
Rizo, VHT
Almeida, LY
Tirapelli, C
Silva-Sousa, YTC
Almeida, OP
Leon, JE
Abstract: OBJECTIVE: To analyze the expression and distribution patterns of mature dendritic cells (mDCs) and immature DCs (imDCs) in radicular cysts (RCs), dentigerous cysts (DtCs), and keratocystic odontogenic tumors (KCOTs). Materials and methods: Forty-nine odontogenic cystic lesions (OCLs) (RCs, n = 20; DtCs, n = 15; KCOTs, n = 14) were assessed using the following markers: S100, CD1a and CD207 for imDCs; and CD83 for mDCs. Results: Almost all cases were S100, CD1a, and CD207 positive, whereas 63% were CD83 positive. RCs presented greater number of immunostained cells, followed by DtCs, and KCOTs. The number of S100+ cells was greater than both CD1a+ and CD207+ cells (P < 0.001), which showed approximately similar amounts, followed by lower number of CD83+ cells (P < 0.001) in each OCL type. Different from S100+ cells, both CD1a+ and CD207+ cells on the epithelium (P < 0.05) and CD83+ cells on the capsule (P < 0.05) were preferentially observed. In RCs, significant correlation was found between the thickness epithelium with S100+ and CD1a+ cells, and between the degree of inflammation with CD83+ cells. Conclusions: Dendritic cell populations in OCLs can be phenotypically heterogeneous, and it could represent distinct lineages and/or functional stages. It is suggested that besides DC-mediated immune cell interactions, DC-mediated tissue differentiation and maintenance in OCLs should also be considered. Oral Diseases (2012) 19, 8591
Subject: odontogenic cysts
dendritic cells
Country: EUA
Editor: Wiley-blackwell
Citation: Oral Diseases. Wiley-blackwell, v. 19, n. 1, n. 85, n. 91, 2013.
Rights: fechado
Identifier DOI: 10.1111/j.1601-0825.2012.01960.x
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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