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Type: Artigo de periódico
Title: Immunological aspects of fresh-frozen allogeneic bone grafting for lateral ridge augmentation
Author: Spin-Neto, R
Stavropoulos, A
de Freitas, RM
Pereira, LAVD
Carlos, IZ
Marcantonio, E
Abstract: Objectives: To present some immunological aspects of fresh-frozen allogeneic bone grafting for lateral bone augmentation, based on the quantitative evaluation of IL-10, IL-1 beta, IFN-gamma and TNF-alpha in patients sera. Material and methods: Thirty-three partially or totally edentulous patients received fresh-frozen allogeneic bone (AL - 20 patients) or autologous bone onlay block grafts (AT - 13 patients) prior to oral implant placement. Blood samples were collected from each patient at various time-points during a 6 month-period (baseline, 14, 30, 90 and 180 days postoperatively). Quantitative evaluation of IL-10, IL-1 beta, IFN-gamma and TNF-alpha was performed by enzyme linked immunosorbent assay (ELISA). Results: For all evaluated markers and at all evaluated periods, inter-group comparisons showed no statistically significant differences between the groups, while the observed values were within normal levels. For AL-treated patients, intra-group evaluation showed statistically significant increase of TNF-a from baseline to 90 (P < 0.001) and 180 (P < 0.01) days, and from 14 to 90 (P < 0.01) and 180 (P < 0.05) days. IFN-gamma showed intercalated results, with a decrease from baseline to 14 days (P < 0.05), and increase from 14 to 90 days (P < 0.001) and 180 (P < 0.05) days. No differences between the periods of evaluation were found for the AT group. Conclusions: AL grafting for lateral bone augmentation, similar to AT grafting, does not seem to challenge the immune system significantly.
Subject: bone allograft
bone autograft
immunological evaluation
ridge augmentation
Country: EUA
Editor: Wiley-blackwell
Citation: Clinical Oral Implants Research. Wiley-blackwell, v. 24, n. 9, n. 963, n. 968, 2013.
Rights: fechado
Identifier DOI: 10.1111/j.1600-0501.2012.02510.x
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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