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Type: Artigo de periódico
Title: Immunohistochemical expression of Skp2 protein in oral nevi and melanoma
Author: Benevenuto-de-Andrade, BA
Leon, JE
Carlos, R
Delgado-Azanero, W
Mosqueda-Taylor, A
Paes-de-Almeida, O
Abstract: Objective: The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oral nevi and 11 primary oral melanomas. Study Design: Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was assessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide. Results: Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of this protein. Conclusion: These results indicate that Skp2 protein may play a role in the development and progression of oral melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral benign and malignant melanocytic lesions.
Subject: Oral melanoma
oral nevi
cell cycle
Country: Espanha
Editor: Medicina Oral S L
Citation: Medicina Oral Patologia Oral Y Cirugia Bucal. Medicina Oral S L, v. 18, n. 3, n. E388, n. E391, 2013.
Rights: aberto
Identifier DOI: 10.4317/medoral.18781
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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