Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/69937
Type: Artigo de periódico
Title: Immunodepression induced by Trypanosoma cruzi and mouse hepatitis virus type 3 is associated with thymus apoptosis
Author: Verinaud, L
Da Cruz-Hofling, MA
Sakurada, JK
Rangel, HA
Vassallo, J
Wakelin, D
Sewell, HF
Camargo, IJB
Abstract: Trypanosoma cruzi-infected mice show disturbance in the peripheral immune system such as polyclonal lymphocyte activation, autoantibody production, and immunosuppression of T lymphocytes, Precious observations in our laboratory showed that some stocks of T. cruzi can be contaminated with mouse hepatitis virus type 3 (MHV-3). Literature has shown that MHV-3 infection induces immunologic disorders characterized by thymic involution with marked cell depletion. However, the effects of interactions between MHV-3 and the parasite on the immune system are not well understood, In the present study specific-pathogen-free CBA mice were inoculated with MHV-3, alone or associated with different stocks of T. cruzi, Concurrent murine virus infection resulted in increased pathogenicity of T. cruzi infection shown by profound thymic atrophy; loss of cortical thymocytes; depletion of Thy1.2(+), CD4(+), and CD8(+) cells; enhancement of in situ labeling of nuclear DNA fragmentation; and eventually, death of the animals, Such lines of evidence show that the mechanism underlying this thymic atrophy is associated with apoptosis, These results also suggest that MHV-3 can account for the increased immunosuppression observed during experimental infection with the parasite.
Country: EUA
Editor: Amer Soc Microbiology
Rights: aberto
Date Issue: 1998
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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