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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleImmunocytochemical localization of cytokines and inducible nitric oxide synthase (NOS) in oral mucosa and lymph nodes of patients with paracoccidioidomycosispt_BR
dc.contributor.authorNeworal, EPMpt_BR
dc.contributor.authorAltemani, Apt_BR
dc.contributor.authorMamoni, RLpt_BR
dc.contributor.authorNoronha, ILpt_BR
dc.contributor.authorBlotta, MHSLpt_BR
unicamp.authorUniv Estadual Campinas, Fac Med Sci,Sch Med, Dept Clin Pathol, UNICAMP, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas, Sch Med, Dept Pathol, UNICAMP, BR-13083970 Campinas, SP, Brazil Univ Sao Paulo, Sch Med, Dept Nephrol, Sao Paulo, SP, Brazilpt_BR
dc.subjectinterleukin-10pt_BR
dc.subjectinducible nitric oxide synthasept_BR
dc.subjectParacoccidioidomycosispt_BR
dc.subjecttransforming growth factor-betapt_BR
dc.subjecttumor necrosis factor-alphapt_BR
dc.subject.wosTumor-necrosis-factorpt_BR
dc.subject.wosBrasiliensis-infected Micept_BR
dc.subject.wosGamma-interferonpt_BR
dc.subject.wosTgf-betapt_BR
dc.subject.wosInterleukin-10pt_BR
dc.subject.wosMacrophagespt_BR
dc.subject.wosResistancept_BR
dc.subject.wosMechanismpt_BR
dc.subject.wosJuvenilept_BR
dc.description.abstractParacoccidioidomycosis (PCM) is a deep mycosis caused by Paracoccidioides brasiliensis, with high incidence in Brazil. In order to examine the immune response in lesional tissue from patients with PCM, we analyzed cytokines as well as the phenotype of the cell infiltrate. Paraffin-embedded tissue from the oral mucosa of eight patients with the localized adult form (AF) of PCM and from the lymph nodes of 10 patients with the juvenile form (JF) of PCM was analyzed by immunohistochemistry to detect tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (NOS), transforming growth factor-beta (TGF-beta) and interleukin-10 (IL-10). Most of the inflammatory cells in the lymph nodes were CD68+ (macrophages, epithelioid and giant cells), while a mixed infiltrate with macrophages, plasma cells and neutrophils was detected in the oral mucosa. TNF-a as well as NOS expression was similar in lymph nodes and oral mucosa, whereas TGF-beta and IL-10 were observed in a larger number of macrophages, epithelioid and giant cells in the lymph nodes, where numerous yeast cells were visualized. The higher expression of anti-inflammatory cytokines (IL-10 and TGF-beta) in lesions of patients with the JF of PCM (lymph nodes) may represent a mechanism by which the fungus evades the host immune response, contributing to a more severe and disseminated form of the disease. (C) 2003 Elsevier Science Ltd. All rights reserved.pt
dc.relation.ispartofCytokinept_BR
dc.relation.ispartofabbreviationCytokinept_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherAcademic Press Ltd Elsevier Science Ltdpt_BR
dc.date.issued2003pt_BR
dc.date.monthofcirculation39142pt_BR
dc.identifier.citationCytokine. Academic Press Ltd Elsevier Science Ltd, v. 21, n. 5, n. 234, n. 241, 2003.pt_BR
dc.language.isoenpt_BR
dc.description.volume21pt_BR
dc.description.issuenumber5pt_BR
dc.description.initialpage234pt_BR
dc.description.lastpage241pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn1043-4666pt_BR
dc.identifier.wosidWOS:000183386700004pt_BR
dc.identifier.doi10.1016/S1043-4666(03)00051-6pt_BR
dc.date.available2014-11-13T20:55:23Z
dc.date.available2015-11-26T17:11:27Z-
dc.date.accessioned2014-11-13T20:55:23Z
dc.date.accessioned2015-11-26T17:11:27Z-
dc.description.provenanceMade available in DSpace on 2014-11-13T20:55:23Z (GMT). No. of bitstreams: 1 WOS000183386700004.pdf: 3941056 bytes, checksum: babca0c71ac7f9412352582abd5b1c18 (MD5) Previous issue date: 2003en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:11:27Z (GMT). No. of bitstreams: 2 WOS000183386700004.pdf: 3941056 bytes, checksum: babca0c71ac7f9412352582abd5b1c18 (MD5) WOS000183386700004.pdf.txt: 25741 bytes, checksum: a8555ec391b9e185a8cfc48f4f02b968 (MD5) Previous issue date: 2003en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69934pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/69934
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69934-
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