Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/69872
Type: Artigo de periódico
Title: Histomorphology and ultrastructure of pancreatic islet tissue during in vivo maturation of rat pancreas
Author: Carvalho, CPDF
Martins, JCR
Da Cunha, DA
Boschero, AC
Collares-Buzato, CB
Abstract: In this study, we have investigated the structural and ultrastructural features of pancreatic islet tissue during rat postnatal development. For this purpose, we used neonatal (1-2 days old), young (21 days old) and adult (3-4 months old) rats. From a functional point of view, neonatal islet tissue displayed a relatively poor insulin secretary response to glucose stimulation in comparison with the adult ones. Histological analysis showed that neonatal islet cells display a less organized morphology in comparison with the young and adult ones, characterized by a less defined form and the presence of ductal structures within or nearby the islet. Regarding the islet cytoarchitecture, no differences were observed among at[ animal groups studied. B-cells were always typically detected within the islet core while A-cells occupied the islet periphery area. No marked differences were found during postnatal animal development regarding the uttrastructural aspect of the endocrine cells and their secretary granules. Nevertheless, quantitative analysis showed a lower B-cell/non-B-cell ratio, a higher association with ducts and an increased immunoreaction for proliferating cell nuclear antigen (PCNA) in neonatal islets as compared to young and adults. In conclusion, the acquisition of an adult pattern of insulin secretion may require an appropriate histoarchitecture and B-cell/non-B-cell proportion that may affect crucial regulatory events such as the paracrine and/or the cell-cell interaction or communication within the islet. (c) 2005 Elsevier GmbH. All rights reserved.
Subject: differentiation
endocrine pancreas
insulin secretion
postnatal
development
morphology
Country: Alemanha
Editor: Elsevier Gmbh, Urban & Fischer Verlag
Rights: fechado
Identifier DOI: 10.1016/j.annat.2005.10.009
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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