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Type: Artigo de periódico
Title: Histometric evaluation of the effect of nicotine administration on periodontal breakdown: an in vivo study
Author: Nociti, FH
Nogueira, GR
Tramontina, VA
Machado, MAV
Barros, SP
Sallum, EA
Sallum, AW
Abstract: The present study investigated the effect of nicotine administration on periodontal breakdown resulting from ligature-induced periodontitis in rats. Twenty adult male Wistar rats were used. After anesthesia, a mandibular first molar was randomly assigned to receive a cotton ligature in the sulcular area while the contralateral tooth was left unligated. The animals were randomly assigned to one of the following treatments, of daily intraperitoneal injections: A - saline solution, B - 0.37 mg of nicotine/kg, C - 0.57 mg of nicotine/kg and D - 0.73 mg of nicotine/kg. Thirty days later, the animals were sacrificed and the specimens routinely processed for serial decalcified sections. Statistical analysis (ANOVA) revealed greater bone loss (p <0.05) in the ligated teeth of animals which received nicotine (groups B/C/D) thin in the ligated teeth of animals which received saline solution (group A). In addition, a dose-dependent response was observed among the nicotine groups. A negative effect of nicotine was observed in the unligated teeth of the experimental groups (p < 0.05). Therefore, daily administration of nicotine enhanced, in a dose-dependent manner, the effects of local factors in producing periodontal breakdown. Furthermore, the nicotine seemed to have a direct deleterious effect on the periodontal tissues.
Subject: nicotine
ligature-induced periodontitis
histometric evaluation
Country: Dinamarca
Editor: Munksgaard Int Publ Ltd
Citation: Journal Of Periodontal Research. Munksgaard Int Publ Ltd, v. 36, n. 6, n. 361, n. 366, 2001.
Rights: fechado
Identifier DOI: 10.1034/j.1600-0765.2001.360603.x
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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