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|Type:||Artigo de periódico|
|Title:||Histometric evaluation of the effect of nicotine administration on periodontal breakdown: an in vivo study|
|Abstract:||The present study investigated the effect of nicotine administration on periodontal breakdown resulting from ligature-induced periodontitis in rats. Twenty adult male Wistar rats were used. After anesthesia, a mandibular first molar was randomly assigned to receive a cotton ligature in the sulcular area while the contralateral tooth was left unligated. The animals were randomly assigned to one of the following treatments, of daily intraperitoneal injections: A - saline solution, B - 0.37 mg of nicotine/kg, C - 0.57 mg of nicotine/kg and D - 0.73 mg of nicotine/kg. Thirty days later, the animals were sacrificed and the specimens routinely processed for serial decalcified sections. Statistical analysis (ANOVA) revealed greater bone loss (p <0.05) in the ligated teeth of animals which received nicotine (groups B/C/D) thin in the ligated teeth of animals which received saline solution (group A). In addition, a dose-dependent response was observed among the nicotine groups. A negative effect of nicotine was observed in the unligated teeth of the experimental groups (p < 0.05). Therefore, daily administration of nicotine enhanced, in a dose-dependent manner, the effects of local factors in producing periodontal breakdown. Furthermore, the nicotine seemed to have a direct deleterious effect on the periodontal tissues.|
|Editor:||Munksgaard Int Publ Ltd|
|Citation:||Journal Of Periodontal Research. Munksgaard Int Publ Ltd, v. 36, n. 6, n. 361, n. 366, 2001.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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