Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/69830
Type: Artigo de periódico
Title: High-pressure phase diagram of the drug mitotane in compressed and/or supercritical CO2
Author: Favareto, R
Pereira, JRD
Santana, CC
Madureira, EH
Cabral, VF
Tavares, FW
Cardozo, L
Abstract: This work provides experimental phase diagram of mitotane, a drug used in the chemotherapy treatment of adrenocortical carcinoma, in compressed and/or supercritical CO2. The synthetic-static method in a high-pressure variable-volume view cell coupled with a transmitted-light intensity probe was used to measure the solid-fluid (SF) equilibrium data. The phase equilibrium experiments were determined in temperature ranging from (298.2 to 333.1) K and pressure up to 22 MPa. Peng-Robinson equation of state (PR-EoS) with classical mixing rule was used to correlate the experimental data. Excellent agreement was found between experimental and calculated values. (C) 2009 Elsevier Ltd. All rights reserved.
Subject: Transmitted-light intensity
Mitotane
CO2
Cubic equation of state
Country: Inglaterra
Editor: Academic Press Ltd- Elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.jct.2009.08.017
Date Issue: 2010
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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