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Type: Artigo de periódico
Title: Outcome of surgical treatment in familial mesial temporal lobe epilepsy
Author: Kobayashi, E
D'Agostino, MD
Lopes-Cendes, I
Andermann, E
Dubeau, F
Guerreiro, CAM
Schenka, AA
Queiroz, LS
Olivier, A
Cendes, F
Andermann, F
Abstract: Purpose: To describe postoperative outcome in patients with familial mesial temporal lobe epilepsy (FMTLE). Methods: We studied FMTLE patients who underwent surgical treatment for refractory seizures. FMTLE was defined when at least two individuals in a family had a clinical EEG diagnosis of MTLE. Preoperative investigation included magnetic resonance imaging (MRI), interictal/ictal EEGs, and neuropsychological evaluation. We used Engel's classification for postoperative outcome. Results: To date, 20 FMTLE patients have been operated on, with 1.6 to 9.8 years of follow-up (mean, 5.5 years). Hippocampal atrophy (HA) and other signs of mesial temporal sclerosis (MTS) were present in 18 patients (15 unilateral). Seizures were recorded in 19 patients. Seventeen (85%) patients are in class I. Two patients had normal hippocampal volumes (HcV): one (5%) is in class 11 and the other (5%) in class IV (extratemporal seizures developed after surgery). One (5%) patient had bilateral HA and is in class III. Qualitative histopathology showed MTS with different degrees of severity. Conclusions: Refractory FMTLE patients have good surgical outcome when unilateral or clearly asymmetric HA is identified. Preoperative investigation should be the same as that in patients with sporadic refractory MTLE.
Subject: surgery
hippocampal atrophy
familial mesial temporal lobe epilepsy
Country: EUA
Editor: Blackwell Publishing Inc
Rights: fechado
Identifier DOI: 10.1046/j.1528-1157.2003.06503.x
Date Issue: 2003
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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