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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleHost-guest interactions between dapsone and beta-cyclodextrin (Part II): thermal analysis, spectroscopic characterization, and solubility studiespt_BR
dc.contributor.authorMartins, MHpt_BR
dc.contributor.authorCalderini, Apt_BR
dc.contributor.authorPessine, FBTpt_BR
unicamp.author.emailmilene@iqm.unicamp.brpt_BR
unicamp.author.emailadrianacalderini@yahoo.com.brpt_BR
unicamp.author.emailfpessine@iqm.unicamp.brpt_BR
unicamp.authorMartins, M. H. Calderini, A. Pessine, F. B. T. Univ Estadual Campinas, Inst Chem, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectDapsonept_BR
dc.subjectbeta-cyclodextrinpt_BR
dc.subjectThermal analysispt_BR
dc.subjectFluorescencept_BR
dc.subjectStability constantpt_BR
dc.subject.wosInclusion Complexationpt_BR
dc.subject.wosGamma-cyclodextrinpt_BR
dc.subject.wosAlpha-cyclodextrinpt_BR
dc.subject.wosAssociationpt_BR
dc.subject.wosStabilitypt_BR
dc.subject.wosSystemspt_BR
dc.description.abstractThe complex of dapsone with beta-cyclodextrin was prepared by the co-precipitation/freeze-drying method. The physical-chemical characteristics of the complex were investigated by different methods and compared with those of the physical mixture and of the isolated compounds. The methods used were infrared spectroscopy, X-ray diffractometry and differential scanning calorimetry. The stability constant was calculated from phase solubility diagram (Higuchi-Connors) and fluorescence spectroscopy. The stoichiometry of the complex was confirmed by Job's plot. Fluorescence measurements at different temperatures provided the thermodynamic parameters of the complexation. The infrared spectrum showed the disappearance of the SO2 asymmetric stretching band of the drug at 1275 cm(-1) after complexation. The amorphization of the samples, as revealed by the X-ray diffraction patterns, was an indirect proof of the inclusion complex. The thermal analysis showed that the curves of the physical mixture are combination of the curves of both constituents (dapsone and beta-cyclodextrin) while the absence of the melting peak of the drug in the DSC curve of the complex suggests the inclusion of the drug molecule in the host cavity as a 1:1 complex as indicated by Job's plot. There was a linear increase in its solubility with the increase of the cyclodextrin concentration and the complex was classified as an A(L)-type. The value of the stability constant was 3,998 L mol(-1) calculated by the Higuchi-Connors diagram and around 18,100 L mol(-1) from the fluorescence method indicating a strong interaction between the host and the guest. Complex formation was a spontaneous and enthalpy directed process.pt
dc.relation.ispartofJournal Of Inclusion Phenomena And Macrocyclic Chemistrypt_BR
dc.relation.ispartofabbreviationJ. Incl. Phenom. Macrocycl. Chem.pt_BR
dc.publisher.cityDordrechtpt_BR
dc.publisher.countryHolandapt_BR
dc.publisherSpringerpt_BR
dc.date.issued2012pt_BR
dc.date.monthofcirculationDECpt_BR
dc.identifier.citationJournal Of Inclusion Phenomena And Macrocyclic Chemistry. Springer, v. 74, n. 41730, n. 109, n. 116, 2012.pt_BR
dc.language.isoenpt_BR
dc.description.volume74pt_BR
dc.description.issuenumber41730pt_BR
dc.description.firstpage109pt_BR
dc.description.lastpage116pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0pt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0923-0750pt_BR
dc.identifier.wosidWOS:000306946700009pt_BR
dc.identifier.doi10.1007/s10847-011-0089-1pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.date.available2014-07-30T18:03:35Z
dc.date.available2015-11-26T17:48:23Z-
dc.date.accessioned2014-07-30T18:03:35Z
dc.date.accessioned2015-11-26T17:48:23Z-
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dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69669
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69669-
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