Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/69656
Type: Artigo de periódico
Title: ORAL ESTRADIOL-17-BETA RAISES THE LEVEL OF PLASMA HIGH-DENSITY-LIPOPROTEIN IN MENOPAUSAL WOMEN BY SLOWING DOWN ITS CLEARANCE RATE
Author: QUINTAO, ECR
NAKANDAKARE, E
OLIVEIRA, HCF
ROCHA, JC
GARCIA, RC
DEMELO, NR
Abstract: Plasma lipoprotein composition, plasma kinetics of autologous [I-125]HDL and the metabolism of iv administered radioactively labelled artificial chylomicrons were studied in postmenopausal women during a control period and after 4 months of oral estradiol-17-beta treatment (1 mg/m2 body surface per day). Drug treatment significantly raised plasma HDL-cholesterol levels (19%) in the fasting state and total apolipoprotein A-I (16%), but did not interfere with triglyceride, VLDL, LDL or apolipoprotein-B values. As compared with the control period, estradiol-17-beta administration significantly slowed down plasma [I-125]HDL clearance by about 82% and reduced the delipidation index of the injected artificial chylomicrons by 47% as a consequence of impaired plasma lipolytic activity.
Country: Noruega
Editor: Scandinavian University Press
Rights: aberto
Date Issue: 1991
Appears in Collections:Unicamp - Artigos e Outros Documentos

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