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|Type:||Artigo de periódico|
|Title:||ORAL ESTRADIOL-17-BETA RAISES THE LEVEL OF PLASMA HIGH-DENSITY-LIPOPROTEIN IN MENOPAUSAL WOMEN BY SLOWING DOWN ITS CLEARANCE RATE|
|Abstract:||Plasma lipoprotein composition, plasma kinetics of autologous [I-125]HDL and the metabolism of iv administered radioactively labelled artificial chylomicrons were studied in postmenopausal women during a control period and after 4 months of oral estradiol-17-beta treatment (1 mg/m2 body surface per day). Drug treatment significantly raised plasma HDL-cholesterol levels (19%) in the fasting state and total apolipoprotein A-I (16%), but did not interfere with triglyceride, VLDL, LDL or apolipoprotein-B values. As compared with the control period, estradiol-17-beta administration significantly slowed down plasma [I-125]HDL clearance by about 82% and reduced the delipidation index of the injected artificial chylomicrons by 47% as a consequence of impaired plasma lipolytic activity.|
|Editor:||Scandinavian University Press|
|Citation:||Acta Endocrinologica. Scandinavian University Press, v. 125, n. 6, n. 657, n. 661, 1991.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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