Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/69638
Type: Artigo de periódico
Title: Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP-2/ACS or autogenous bone grafts: a proof-of-concept randomized clinical trial
Author: de Freitas, RM
Susin, C
Spin-Neto, R
Marcantonio, C
Wikesjo, UME
Pereira, LAVD
Marcantonio, E
Abstract: Aim: To compare the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior maxilla. Methods: Twenty-four subjects were enrolled in a randomized, controlled, parallel-group, open-label clinical trial. Subjects either received rhBMP-2/ACS (1.5mg/ml) or particulated autogenous bone harvested from the mandibular retromolar region. A titanium-mesh was used to provide space and wound stability. A guide was used to standardize clinical recordings using an analogue caliper. Alveolar ridge width was also assessed using cone-beam computed tomography. Results: rhBMP-2/ACS yielded significantly greater radiographic horizontal bone gain compared with autogenous bone graft at immediate subcrestal levels (1.5 +/- 0.7 versus 0.5 +/- 0.9mm; p=0.01); non-significant differences were observed at mid- (2.9 +/- 0.8 versus 2.9 +/- 0.9mm; p=0.98) and apical (1.7 +/- 0.9 versus 1.8 +/- 1.1mm; p=0.85) crestal levels. No significant differences in clinical horizontal bone gain were observed at 6months between rhBMP-2/ACS and autogenous bone graft (3.2 +/- 0.9mm versus 3.7 +/- 1.4mm; p=0.31). Sixty-two implants were placed after 6month of healing with no significant differences between groups for number of implants, implant size, primary stability and survival. Conclusions: rhBMP-2/ACS appears a realistic alternative for augmentation of the edentulous atrophic anterior maxilla.
Subject: alveolar ridge augmentation
autogenous bone graft
randomized-controlled trial
recombinant human bone morphogenetic protein
rhBMP-2
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1111/jcpe.12148
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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