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|Type:||Artigo de periódico|
|Title:||Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP-2/ACS or autogenous bone grafts: a proof-of-concept randomized clinical trial|
|Author:||de Freitas, RM|
|Abstract:||Aim: To compare the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior maxilla. Methods: Twenty-four subjects were enrolled in a randomized, controlled, parallel-group, open-label clinical trial. Subjects either received rhBMP-2/ACS (1.5mg/ml) or particulated autogenous bone harvested from the mandibular retromolar region. A titanium-mesh was used to provide space and wound stability. A guide was used to standardize clinical recordings using an analogue caliper. Alveolar ridge width was also assessed using cone-beam computed tomography. Results: rhBMP-2/ACS yielded significantly greater radiographic horizontal bone gain compared with autogenous bone graft at immediate subcrestal levels (1.5 +/- 0.7 versus 0.5 +/- 0.9mm; p=0.01); non-significant differences were observed at mid- (2.9 +/- 0.8 versus 2.9 +/- 0.9mm; p=0.98) and apical (1.7 +/- 0.9 versus 1.8 +/- 1.1mm; p=0.85) crestal levels. No significant differences in clinical horizontal bone gain were observed at 6months between rhBMP-2/ACS and autogenous bone graft (3.2 +/- 0.9mm versus 3.7 +/- 1.4mm; p=0.31). Sixty-two implants were placed after 6month of healing with no significant differences between groups for number of implants, implant size, primary stability and survival. Conclusions: rhBMP-2/ACS appears a realistic alternative for augmentation of the edentulous atrophic anterior maxilla.|
|Subject:||alveolar ridge augmentation|
autogenous bone graft
recombinant human bone morphogenetic protein
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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