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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleHOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome - Brazilian Metabolic Syndrome Study (BRAMS)pt_BR
dc.contributor.authorGeloneze, Bpt_BR
dc.contributor.authorVasques, ACJpt_BR
dc.contributor.authorStabe, CFCpt_BR
dc.contributor.authorPareja, JCpt_BR
dc.contributor.authorRosado, LEFPDpt_BR
dc.contributor.authorde Queiroz, ECpt_BR
dc.contributor.authorTambascia, MApt_BR
unicamp.author.emailbgeloneze@terra.com.brpt_BR
unicamp.authorGeloneze, Bruno Univ Estadual Campinas, Limed, Inst Nacl Ciencia & Tecnol, BR-13081970 Campinas, SP, Brazilpt_BR
unicamp.authorPaez de Lima Rosado, Lina Enriqueta Frandsen Univ Fed Vicosa, Dept Nutr & Saude, Vicosa, MG, Brazilpt_BR
dc.subjectHomeostasis model assessmentpt_BR
dc.subjectmetabolic syndromept_BR
dc.subjectinsulin resistancept_BR
dc.subjectabdominal obesitypt_BR
dc.subject.wosHomeostasis Model Assessmentpt_BR
dc.subject.wosCardiovascular-diseasept_BR
dc.subject.wosNormal-weightpt_BR
dc.subject.wosPrevalencept_BR
dc.subject.wosPlasmapt_BR
dc.subject.wosQuantificationpt_BR
dc.subject.wosPopulationpt_BR
dc.subject.wosOverweightpt_BR
dc.subject.wosGlucosept_BR
dc.subject.wosObesitypt_BR
dc.description.abstractObjective: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. Methods: Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 9011 percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. Results: In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p < 0.001). The cut-off values for IR were: HOMA1-IR > 2.7 and HOMA2-IR > 1.8; and, for MS were: HOMA1-IR > 2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR > 1.4 (sensitivity: 79.2%; specificity: 61.2%). Conclusions: The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations. Arq Bras Endocrinol Metab. 2009;53(2):281-287.pt
dc.relation.ispartofArquivos Brasileiros De Endocrinologia E Metabologiapt_BR
dc.relation.ispartofabbreviationArq. Bras. Endocrinol. Metabol.pt_BR
dc.publisher.cityRio De Janeiro, Rjpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherSbem-soc Brasil Endocrinologia & Metabologiapt_BR
dc.date.issued2009pt_BR
dc.date.monthofcirculationMARpt_BR
dc.identifier.citationArquivos Brasileiros De Endocrinologia E Metabologia. Sbem-soc Brasil Endocrinologia & Metabologia, v. 53, n. 2, n. 281, n. 287, 2009.pt_BR
dc.language.isoenpt_BR
dc.description.volume53pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage281pt_BR
dc.description.lastpage287pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0004-2730pt_BR
dc.identifier.wosidWOS:000265288400020pt_BR
dc.date.available2014-07-30T18:03:27Z
dc.date.available2015-11-26T17:48:12Z-
dc.date.accessioned2014-07-30T18:03:27Z
dc.date.accessioned2015-11-26T17:48:12Z-
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dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69604
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69604-
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