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Type: Artigo de periódico
Title: HLA-DRB1*04 and HLA-DQB1*03 association with the atrophic but not with the goitrous form of chronic autoimmune thyroiditis in a Brazilian population
Author: Zantut-Wittmann, DE
Persoli, L
Tambascia, MA
Fischer, E
Maldonado, DF
Costa, AM
Pavin, EJ
Abstract: Autoimmune chronic lymphocytic thyroiditis appears in two forms, goitrous and atrophic. The evidence available is not enough to prove that the goitrous precedes the atrophic form, but immunogenetic analysis suggests that they may be distinct entities. The distribution of HLA class II alleles DRB1* and DQB1* was verified in patients from the region of Campinas, SAo Paulo, Brazil with both forms of thyroiditis. Ninety-one patients with primary hypothyroidism through autoimmune thyroiditis were classified as goitrous - 54 patients, 42.27 +/- 11.72 years old, having had hypothyroidism for 8.57 +/- 6.63 years - or atrophic 37 patients, 42.72 +/- 12.01 years old, hypothyroidism for 6.73 +/- 4.07 years. The distribution of class II alleles was deter- mined, DRB1* and DQB1* were genotyped after purifying DNA blood samples using the DNAzol technique, and the low-resolution PCR-SSP system was utilized for determination of generic alleles. Chi-square and Fisher's exact test were utilized to compare the distribution frequency of HLA alleles and the significant p-values were subjected to Bonferroni correction. We have demonstrated that the DRB1*04 allele is associated with autoimmune thyroiditis, and that there are genotypic differences regarding the presentation forms with a strong association between DRB1 *04 and DQB1*03 and the atrophic form only.
Subject: autoimmunity
HLA typing
goitrous autoimmune thyroiditis
atrophic autoimmune thyroiditis
Country: Alemanha
Editor: Georg Thieme Verlag Kg
Citation: Hormone And Metabolic Research. Georg Thieme Verlag Kg, v. 36, n. 7, n. 492, n. 500, 2004.
Rights: aberto
Identifier DOI: 10.1055/s-2004-825732
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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