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Type: Artigo de periódico
Title: HIV-associated neuromuscular weakness syndrome in Brazil - Report of the two first cases
Author: Vidal, JE
Clifford, D
Ferreira, CM
de Oliveira, ACP
Abstract: We describe two Brazilian patients with HIV-associated neuromuscular weakness syndrome (HANWS), a unique clinical toxic syndrome that was recently reported in developed countries. Both patients were women, used stavudine and had hyperlactatemia, one of them with lactic acidosis. Eletrophysiological studies were consistent with axonal neuropathy. After discontinuation of antiretroviral therapy the patients had significant improvement in neurologic manifestations, and normalization of lactate levels. To our knowledge, this is the first report of HANWS in developing countries. Growing use of antiretroviral therapy in this setting, particularly stavudine, make it likely that similar cases will be observed.
Subject: neuromuscular diseases
peripheral neuropathies
antiretroviral agents
human immunodeficiency virus
Country: Brasil
Editor: Assoc Arquivos Neuro- Psiquiatria
Citation: Arquivos De Neuro-psiquiatria. Assoc Arquivos Neuro- Psiquiatria, v. 65, n. 3B, n. 848, n. 851, 2007.
Rights: aberto
Identifier DOI: 10.1590/S0004-282X2007000500024
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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