Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/69568
Type: Artigo de periódico
Title: HIV-1 anti-retroviral drug effect on the C-albicans hyphal growth rate by a bio-cell tracer system
Author: de Melo, NR
Vilela, MMS
Jorge, J
Kamei, K
Miyaji, M
Fukushima, K
Nishimura, K
Groeneveld, P
Kelly, SL
Taguchi, H
Abstract: Declining incidence of oropharyngeal candidosis and opportunistic infections over recent years can be attributed to the use of highly active anti-retroviral therapy ( HAART). Infection with C. albicans generally involves adherence and colonization of superficial tissues. During this process, budding yeasts are able to transform to hyphae and penetrate into the deep tissue. Using the biocell tracer system, C. albicans hyphal growth was dynamically observed at the cellular level. Ritonavir was effective in the inhibition of hyphal growth with growth rate of 0.8 mu m/min. This study showed the in vitro effect of HIV anti-retroviral drug on the growth rate of the C. albicans hyphae.
Subject: Candida
hyphal
protease inhibitor
Country: Brasil
Editor: Soc Brasileira Microbiologia
Rights: aberto
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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