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Type: Artigo de periódico
Title: Opposite effects of Mn(III) and Fe(III) forms of meso-tetrakis(4-N-methyl pyridiniumyl) porphyrins on isolated rat liver mitochondria
Author: Nepomuceno, MF
Tabak, M
Vercesi, AE
Abstract: The relevance of porphyrins as therapeutic drugs targeted to mitochondria has been widely recognized. In this work, we studied the action of meso-tetrakis porphyrins (TMPyP) on respiring rat liver mitochondria. Mn(III)TMPyP exerted a protective effect against lipid peroxidation induced by Fe(II) or the azo initiator 4,4'-azobis(4-cyanopentanoic acid) (ABCPA), which partition in the hydrophobic phospholipid moiety, and 2,2'-azobis(2-amidinepropane)dihydrochloride (ABAP), which partitions in the aqueous phase, In contrast, Fe(III)TMPyP itself induced an intense lipid peroxidation, accompanied by mitochondrial permeability transition. Both mesoporphyrins studied promoted a release of mitochondrial state-4 respiration, in the concentration range of 1.0-20 muM. Based on the relative effects of Mn(III)TMPyP against ABAP and ABCPA-induced lipid peroxidation, we believe that meso-tetrakis porphyrins must concentrate preferably at membrane-water interfaces.
Subject: oxygen consumption
free radicals
oxidative stress
photodynamic therapy
Country: EUA
Editor: Kluwer Academic/plenum Publ
Citation: Journal Of Bioenergetics And Biomembranes. Kluwer Academic/plenum Publ, v. 34, n. 1, n. 41, n. 47, 2002.
Rights: fechado
Identifier DOI: 10.1023/A:1013818719932
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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