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|Type:||Artigo de periódico|
|Title:||In vivo preservation of the hybrid layer by chlorhexidine|
de Goes, MF
|Abstract:||Host-derived proteases have been reported to degrade the collagen matrix of incompletely-resinin-filtrated dentin. This study tested the hypothesis that interfacial degradation of resin-dentin bonds may be prevented or delayed by the application of chlorhexidine (CHX), a matrix metalloproteinase inhibitor, to dentin after phosphoric acid-etching. Contralateral pairs of resin-bonded Class I restorations in non-carious third molars were kept under intra-oral function for 14 months. Preservation of resin-dentin bonds was assessed by microtensile bond strength tests and TEM examination. In vivo bond strength remained stable in the CHX-treated specimens, while bond strength decreased significantly in control teeth. Resin-infiltrated dentin in CHX-treated specimens exhibited normal structural integrity of the collagen network. Conversely, progressive disintegration of the fibrillar network was identified in control specimens. Auto-degradation of collagen matrices can occur in resin-infiltrated dentin, but may be prevented by the application of a synthetic protease inhibitor, such as chlorhexidine.|
|Editor:||Int Amer Assoc Dental Researchi A D R/a A D R|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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