Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/69441
Type: Artigo de periódico
Title: In vivo interaction of cells on poly L-(lactic acid) membranes containing plasticizer
Author: Silva, DRM
Scapin, SMN
Joazeiro, PP
Alberto-Rincon, MC
Luciano, RM
Duek, EAR
Abstract: The development of biodegradable materials has lead to renewed interest in the study of their interactions with the host organism in order to make the resulting products appropriate for use as temporary materials in protheses. Poly L-(lactic acid)(PLLA)-based biodegradable devices have been used for several purposes. The physical properties of these materials can be modified by the addition of a plasticizer, such as the triethylcitrate, to provide flexibility and porosity to the implants and enhance control of the polymer degradation time. In this work we examined the biological properties of a PLLA porous membrane containing 7% triethylcitrate, by assessing the process of degradation and the interaction with dermal tissue. Samples of skin obtained from female Wistar rats 2-180 days after implantation with PLLA-based membrane were processed for light microscopy and scanning electron microscopy. The membranes became surrounded by a delicate network of connective tissue which gradually invaded the membrane structure. Polymer degradation began with the appearance of radial fractures in the globular units of the biodegradable membrane, especially by 90 and 180 days after implantation. (C) 2002 Kluwer Academic Publishers.
Country: Holanda
Editor: Kluwer Academic Publ
Rights: fechado
Identifier DOI: 10.1023/A:1014027405057
Date Issue: 2002
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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