Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/69429
Type: Artigo de periódico
Title: In vivo antitumoural activity and composition of an oil extract of Brazilian propolis
Author: Carvalho, AA
Finger, D
Machado, CS
Schmidt, EM
da Costa, PM
Alves, APNN
Morais, TMF
de Queiroz, MGR
Quinaia, SP
da Rosa, MR
dos Santos, JMT
Pessoa, C
de Moraes, MO
Costa-Lotufo, LV
Sawaya, ACHF
Eberlin, MN
Torres, YR
Abstract: The present study aimed to evaluate in vivo and in vitro the antitumoural activity of a propolis extract obtained with edible vegetable oil and its fractions and also to investigate its chemical composition by LC-MS and LC-MS/MS. To evaluate the toxicological aspects related to the propolis extract treatment, hematological, biochemical, histopathological and morphological analyses of treated animals were performed. All propolis extracts showed an in vivo antitumour activity in the experimental model with a moderate toxicity effect at experimental exposure levels. The oil extract was as effective as the ethanolic extract at inhibiting tumour growth. In vitro assays showed that the whole oil extract produced better inhibition of tumour cells than its fractions. LC-MS and LC-MS/MS identified four phenolic acids and three flavonoids. The anticancer potential of the oil extract of propolis has been demonstrated and the edible vegetable oil was shown as an attractive alternative solvent to extract bioactive natural propolis components. (C) 2010 Elsevier Ltd. All rights reserved.
Subject: Propolis
Edible oil extract
Antitumour activity
Phenolic compounds
Country: Inglaterra
Editor: Elsevier Sci Ltd
Rights: fechado
Identifier DOI: 10.1016/j.foodchem.2010.12.035
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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