Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/69414
Type: Artigo de periódico
Title: In vitro studies on the release of isoniazid incorporated in poly(epsilon-caprolactone)
Author: Duran, N
De Oliveira, AF
De Azevedo, MMM
Abstract: A polymeric micro- and nanosphere formulation using poly (E-caprolactone) (PCL) to entrap an antituberculosis drug, isoniazid (INH), was developed and characterized. The microspheres were prepared by a solvent evaporation method using ethyl acetate, PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. The nanospheres were prepared by a spontaneous emulsification solvent diffusion method using 40% ethanol in acetone (v/v), PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. After freeze-drying, these systems were characterized by scanning electron microscopy (SEM), particle size analysis, determination of entrapped INH content, in vitro INH release and brine shrimp toxicity bioassay.
Subject: microparticles
antituberculosis
isoniazid
poly (epsilon-caprolactone)
drug toxicity
Country: Itália
Editor: Esift Srl
Rights: fechado
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File Description SizeFormat 
WOS000242009200004.pdf289.14 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.