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|Type:||Artigo de periódico|
|Title:||In vitro studies on the release of isoniazid incorporated in poly(epsilon-caprolactone)|
De Oliveira, AF
De Azevedo, MMM
|Abstract:||A polymeric micro- and nanosphere formulation using poly (E-caprolactone) (PCL) to entrap an antituberculosis drug, isoniazid (INH), was developed and characterized. The microspheres were prepared by a solvent evaporation method using ethyl acetate, PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. The nanospheres were prepared by a spontaneous emulsification solvent diffusion method using 40% ethanol in acetone (v/v), PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. After freeze-drying, these systems were characterized by scanning electron microscopy (SEM), particle size analysis, determination of entrapped INH content, in vitro INH release and brine shrimp toxicity bioassay.|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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