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Type: Artigo de periódico
Title: In Vitro Evaluation of the Type of Interaction Obtained by the Combination of Terbinafine and Itraconazole, Voriconazole, or Amphotericin B against Dematiaceous Molds
Author: Biancalana, FSC
Lyra, L
Schreiber, AZ
Abstract: In vitro associations using the checkerboard microdilution method indicated lower MIC ranges and MIC median values for each drug (terbinafine, itraconazole, voriconazole, and amphotericin B) in association than those obtained for each single drug. Fractional inhibitory concentration index (FIC) results showed 100% synergism in the association of terbinafine with voriconazole, 96.5% in the association of terbinafine with amphotericin B, and 75.9% in the association of terbinafine with itraconazole. Drug combinations may be useful for treatment of dematiaceous mold infections as an alternative treatment to enhance the effectiveness of each drug.
Country: EUA
Editor: Amer Soc Microbiology
Citation: Antimicrobial Agents And Chemotherapy. Amer Soc Microbiology, v. 55, n. 9, n. 4485, n. 4487, 2011.
Rights: aberto
Identifier DOI: 10.1128/AAC.01015-10
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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