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Type: Artigo de periódico
Title: In vitro Effect of a New Cinnamic Acid Derivative Against the Epimastigote Form of Trypanosoma cruzi
Author: Andreu, GLP
Inada, NM
Pellon, RF
Docampo, ML
Fascio, ML
D'Accors, NB
Vercesi, AE
Abstract: An intensive effort has been directed toward finding alternative drugs for treatment of Chagas' disease, caused by Trypanosoma cruzi (T. cruzi), and prophylaxis of blood in endemic areas. The preparation and in vitro evaluation as potential anti-protozoal agent of (2E)-N-(1,3-benzothiazol-2-yl)-3-(2,5-di- methoxyphenyl)-2-propenamide (CAD-1) is presented. The results show that 0.05 mM CAD-1 induced 58.1 % of T. cruzi epimastigotes death; mainly by apoptosis. The diminution in the transmembrane mitochondrial electrical potential together with the increase in the intracellular generation/accumulation of reactive oxygen species, suggest the parasites mitochondria as the main target for CAD-1 induced death. The concentration of 0.05 mM CAD-1 is not low enough to consider it as a potent tripanocydal agent. However the novel mechanism that induces T. cruzi death, together with the novelty of its chemical structure, point out CAD-1 as a head group compound that could serve as a template to obtain new, more potent anti-Chagas disease agents.
Subject: Anti-protozoal agents
Chagas' disease
Cinnamic acid
Oxidative stress
Trypanosoma cruzi
Country: Alemanha
Editor: Ecv-editio Cantor Verlag Medizin Naturwissenschaften
Rights: aberto
Date Issue: 2009
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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