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Type: Artigo de periódico
Title: In vitro antiviral activity of Brazilian plants (Maytenus ilicifolia and Aniba rosaeodora) against bovine herpesvirus type 5 and avian metapneumovirus
Author: Kohn, LK
Queiroga, CL
Martini, MC
Barata, LE
Porto, PSS
Souza, L
Arns, CW
Abstract: Context: Medicinal plants are well known for their use in traditional folk medicine as treatments for many diseases including infectious diseases. Objective: Six Brazilian medicinal plant species were subjected to an antiviral screening bioassay to investigate and evaluate their biological activities against five viruses: bovine herpesvirus type 5 (BHV-5), avian metapneumovirus (aMPV), murine hepatitis virus type 3, porcine parvovirus and bovine respiratory syncytial virus. Materials and methods: The antiviral activity was determined by a titration technique that depends on the ability of plant extract dilutions (25 or 2.5 mu g/mL) to inhibit the viral induced cytopathic effect and the extracts' inhibition percentage (IP). Results: Two medicinal plant species showed potential antiviral activity. The Aniba rosaeodora Ducke (Lauraceae) extract had the best results, with 90% inhibition of viral growth at 2.5 mu g/mL when the extract was added during the replication period of the aMPV infection cycle. The Maytenus ilicifolia (Schrad.) Planch. (Celastraceae) extracts at a concentration of 2.5 mu g/mL exhibited antiviral activity during the attachment phase of BHV-5 (IP = 100%). Discussion and conclusion: The biomonitored fractionation of the active extracts from M. ilicifolia and A. rosaeodora could be a potential tool for identifying their active compounds and determining the exact mechanism of action.
Subject: Antiviral
crude extract
sulforhodamine B
Country: Inglaterra
Editor: Informa Healthcare
Citation: Pharmaceutical Biology. Informa Healthcare, v. 50, n. 10, n. 1269, n. 1275, 2012.
Rights: fechado
Identifier DOI: 10.3109/13880209.2012.673627
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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