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|Type:||Artigo de periódico|
|Title:||In vitro antiviral activity of Brazilian plants (Maytenus ilicifolia and Aniba rosaeodora) against bovine herpesvirus type 5 and avian metapneumovirus|
|Abstract:||Context: Medicinal plants are well known for their use in traditional folk medicine as treatments for many diseases including infectious diseases. Objective: Six Brazilian medicinal plant species were subjected to an antiviral screening bioassay to investigate and evaluate their biological activities against five viruses: bovine herpesvirus type 5 (BHV-5), avian metapneumovirus (aMPV), murine hepatitis virus type 3, porcine parvovirus and bovine respiratory syncytial virus. Materials and methods: The antiviral activity was determined by a titration technique that depends on the ability of plant extract dilutions (25 or 2.5 mu g/mL) to inhibit the viral induced cytopathic effect and the extracts' inhibition percentage (IP). Results: Two medicinal plant species showed potential antiviral activity. The Aniba rosaeodora Ducke (Lauraceae) extract had the best results, with 90% inhibition of viral growth at 2.5 mu g/mL when the extract was added during the replication period of the aMPV infection cycle. The Maytenus ilicifolia (Schrad.) Planch. (Celastraceae) extracts at a concentration of 2.5 mu g/mL exhibited antiviral activity during the attachment phase of BHV-5 (IP = 100%). Discussion and conclusion: The biomonitored fractionation of the active extracts from M. ilicifolia and A. rosaeodora could be a potential tool for identifying their active compounds and determining the exact mechanism of action.|
|Citation:||Pharmaceutical Biology. Informa Healthcare, v. 50, n. 10, n. 1269, n. 1275, 2012.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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