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Type: Artigo de periódico
Title: In vitro antiproliferative effect of beta-phenylethylamine derivatives and doxorubicin combinations on MCF/ADR cell lines
Author: Almeida, WP
Huber, PC
Kohn, LK
de Carvalho, JE
Abstract: A series of 3,4-dimethoxyphenylethylamine derivatives was prepared from Baylis-Hillman (BH) adducts. The effect of these compounds on the proliferation of breast cancer cell lines (MCF-7) and the corresponding Doxorubicin (Dox) resistant cell lines (MCF-7/ADR) was studied. Aminoalcohols 1a-d were obtained from the Michael addition reaction of 3,4-dimethoxyphenylethylamine and BH adducts. For the preparation of unsaturated amines 2a-d, BH adducts were converted into allylic bromides by treatment with HBr in acidic solution. N-nucleophile introduction could be controlled by the choice of solvent furnishing the corresponding amines 2a-d. A third class of amines (3a-c) was prepared by hydrogenation reaction of amines 2a-d. In respect of the biological evaluation, some of the synthesized compounds exhibited moderate inhibitory effect on the cell growth. In addition, in MCF-7/ADR cell lines, the antiproliferative effect of Dox shifted from 5 to 88 % when co-administrated with compound 2b.
Subject: Phenylethylamines
Multidrug resistance
Country: EUA
Editor: Springer Birkhauser
Citation: Medicinal Chemistry Research. Springer Birkhauser, v. 22, n. 2, n. 548, n. 557, 2013.
Rights: fechado
Identifier DOI: 10.1007/s00044-012-0050-x
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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