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Type: Artigo de periódico
Title: Hypertriglyceridemia increases mitochondrial resting respiration and susceptibility to permeability transition
Author: Alberici, LC
Oliveira, HCF
Bighetti, EJB
de Faria, EC
Degaspari, GR
Souza, CT
Vercesi, AE
Abstract: High plasma level of triglycerides (TGs) is a common feature in atherosclerosis, obesity, diabetes, alcoholism, stress, and infection. Since mitochondria have been implicated in cell death under a variety of metabolic disorders, we examined liver mitochondrial functions in hypertriglyceridemic transgenic mice. Hypertriglyceridemia increased resting respiration and predisposed to mitochondrial permeability transition (MPT). Ciprofibrate therapy reduced plasma TG levels, normalized respiration, and prevented MPT. The higher resting respiration in transgenic mitochondria remained in the presence of the adenine nucleotide carrier inhibitor, carboxyatractyloside, bovine serum albumin, and the uncoupling proteins (UCPs) inhibitor, GDP. UCP2 content was similar in both control and transgenic mitochondria. We propose that faster resting respiration represents a regulated adaptation to oxidize excess free fatty acid in the transgenic mice.
Country: EUA
Editor: Kluwer Academic/plenum Publ
Rights: fechado
Identifier DOI: 10.1023/A:1027343915452
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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