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Type: Artigo de periódico
Title: Hypertension May Affect Tooth-Supporting Alveolar Bone Quality: A Study in Rats
Author: Bastos, MF
Brilhante, FV
Goncalves, TED
Pires, AG
Napimoga, MH
Marques, MR
Duarte, PM
Abstract: Background: This study evaluates the ligature-induced bone loss (BL) and quality of tooth-supporting alveolar bone in spontaneously hypertensive rats (SHRs) by histometric, histochemical, and immunohistochemical analyses and assesses the effects of lercanidipine on these parameters. Methods: Wistar rats and SHRs were assigned to one of the following groups: normotensive rats (n = 15), untreated SHRs (n = 15), and treated SHRs (n = 15). The latter group was treated daily with lercanidipine for 45 days. Two weeks after the beginning of drug administration, the first right mandibular molar received a cotton ligature, whereas the contralateral tooth was left unligated. The following parameters were analyzed in the furcation area of decalcified histologic sections: BL, bone density (BD), number of positive cells for tartrateresistant acid phosphatase (TRAP+), and expression of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG). Results: In ligated teeth, no significant differences among groups were found regarding BL, TRAP+ cells, and the ratio of RANKL/OPG+ cells (P >0.05), although the expression of RANKL was decreased in the treated SHR group (P <0.05). Increased BL and decreased BD were observed around unligated teeth of the untreated and treated SHR groups (P <0.05). In the furcation area of the unligated teeth, the untreated SHR group presented a higher number of TRAP+ cells and higher ratio of RANKL/OPG+ cells compared to the other groups. Conclusions: SHRs present harmful alterations in the quality of tooth-supporting bone, independently of inflammation. In addition, the administration of lercanidipine for 45 days decreased the expression of bone-resorption markers. J Periodontol 2010,81:1075-1083.
Subject: Alveolar bone loss
RANK ligand
tartrate-resistant acid phosphatase
Country: EUA
Editor: Amer Acad Periodontology
Rights: fechado
Identifier DOI: 10.1902/jop.2010.090705
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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