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Type: Artigo de periódico
Title: Hyperbaric oxygen therapy reduces the size of Leishmania amazonensis-induced soft tissue lesions in mice
Author: Arrais-Silva, WW
Pinto, EF
Rossi-Bergmann, B
Giorgio, S
Abstract: In this study we determined whether exposing mice to hyperbaric oxygen (HBO) would alter various disease parameters of a susceptible mouse strain infected with Leishmania amazonensis. BALB/c mice exposed to HBO (100% O-2 at a pressure of 2.5 ATA, 1 h before parasite inoculation and subsequently for 20 days) showed significant delay in lesion development and reduction in lesion parasite burdens compared with HBO-unexposed mice. Circulating levels of interferon gamma (IFN-gamma) and tumor necrosis factor (TNF-alpha) were significantly elevated in HBO-exposed as compared to HBO-unexposed mice. Concanavalin A-stimulated lymph nodes cultures from HBO-exposed mice released significantly more IFN-gamma and less interleukin 10 (IL-10) than cultures from HBO-unexposed mice, consistent with a skewed Th1 response. These results demonstrate, for the first time, that HBO can play a pathogen control role during leishmaniasis. Further studies are needed to elucidate whether hyperoxia alone or increased atmospheric pressure alone can exert a similar effect. (c) 2006 Elsevier B.V. All rights reserved.
Subject: leishmaniasis
Leishmania amazonensis
hyperbaric oxygen
Country: Holanda
Editor: Elsevier Science Bv
Citation: Acta Tropica. Elsevier Science Bv, v. 98, n. 2, n. 130, n. 136, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.actatropica.2006.03.001
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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