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Type: Artigo de periódico
Title: Hyaluronan in vaginal secretions: association with recurrent vulvovaginal candidiasis
Author: Lev-Sagie, A
Nyirjesy, P
Tarangelo, N
Bongiovanni, AM
Bayer, C
Linhares, IM
Giraldo, PC
Ledger, WJ
Witkin, SS
Abstract: OBJECTIVE: We evaluated whether vaginal concentrations of hyaluronan were altered in women with recurrent vulvovaginal candidiasis (RVVC). STUDY DESIGN: Lavage samples from 17 women with acute RVVC, 27 women who were receiving a maintenance antifungal regimen, and 24 control women were tested for hyaluronan and interleukin (IL)-6, IL-12, and IL-23 by enzyme-linked immunosorbent assay. RESULTS: Median vaginal hyaluronan concentrations were 33.8 ng/mL (range, 21.6-66.3 ng/mL) in women with acute RVVC, 15.0 ng/mL (range, 11.2-50.6 ng/mL) in women who were receiving maintenance therapy, and 4.2 ng/mL (range, 3.6-12.0 ng/mL) in control subjects (P <= .02). The vaginal hyaluronan concentration was 27.4 ng/mL (range, 15.4-37.7 ng/mL) when Candida was detected by microscopy and 9.5 ng/mL (range, 7.7-14.6 ng/mL) in microscopy-negative cases (P = .0354). Elevated hyaluronan levels were associated with itching plus burning (40.7 ng/mL) or itching plus discharge (42.1 ng/mL), as opposed to itching only (6.2 ng/mL; P = .0152). Hyaluronan and IL-6 levels were correlated (P = .0009). CONCLUSION: Hyaluronan release is a component of the host response to a candidal infection and may contribute to symptoms.
Subject: anti-Candida maintenance therapy
recurrent vulvovaginal candidiasis
vaginal lavage
Country: EUA
Editor: Mosby-elsevier
Citation: American Journal Of Obstetrics And Gynecology. Mosby-elsevier, v. 201, n. 2, 2009.
Rights: fechado
Identifier DOI: 10.1016/j.ajog.2009.05.010
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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