Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/68918
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleHuman papillomavirus detection by Hybrid Capture II and residual or recurrent high-grade squamous cervical intraepithelial neoplasia after large loop excision of the transformation zone (LLETZ)pt_BR
dc.contributor.authorSarian, LOpt_BR
dc.contributor.authorDerchain, SFMpt_BR
dc.contributor.authorPitta, DDpt_BR
dc.contributor.authorAndrade, LAApt_BR
dc.contributor.authorMorais, SSpt_BR
dc.contributor.authorFigueiredo, PGpt_BR
unicamp.author.emailsarian@fcm.unicamp.brpt_BR
unicamp.authorUniv Estadual Campinas, Dept Gynecol & Obstet, Campinas, Brazil Univ Estadual Campinas, Dept Pathol, Campinas, Brazilpt_BR
dc.subjectcervical intraepithelial neoplasiapt_BR
dc.subjectfollow-uppt_BR
dc.subjecthuman papillomaviruspt_BR
dc.subjecttreatmentpt_BR
dc.subject.wosCold-knife Conizationpt_BR
dc.subject.wosDeoxyribonucleic-acidpt_BR
dc.subject.wosLesionspt_BR
dc.subject.wosWomenpt_BR
dc.subject.wosPersistencept_BR
dc.subject.wosInfectionpt_BR
dc.subject.wosOutcomespt_BR
dc.description.abstractAims and background: The purpose of this study was to assess the association between highly-oncogenic types HPV DNA detection by Hybrid Capture II (HCII) and residual or recurrent high-grade cervical intraepithelial neoplasia (CIN 2 or 3) during the follow-up of women submitted to large loop excision of the transformation zone (LLETZ). Study design: In this cohort study, 94 women submitted to LLETZ because of CIN 2 or 3 between March 2001 and September 2002 were followed up twice yearly until September 2003. Follow-up visits consisted of an interview regarding clinical, social and demographic characteristics complemented with gynecological examination with specimen collection for Pap test and HCII and colposcopy. Eighty-one patients attended the first visit (mean 4.8 months, range 3-6) and 75 the second visit (mean 10.9 months, range 7-17 months). McNemar's test to assess the variation of HPV DNA detection following LLETZ, odds ratios (OR) to evaluate the correlation between HPV DNA positivity and residual/recurrent CIN during follow-up, and logistic regression to assess the risk of residual/recurrent CIN were used. Results: There was a strong and significant reduction in HPV detection after LLETZ (P < 0.001). HPV DNA detection was correlated with residual/recurrent CIN at the first (OR = 103.4; 95% Cl 5.5 to 1961.2) and second (OR = 12.7; 95% Cl 1.1 to 345.5) follow-up visits. Multivariate analysis showed HPV persistence as a stand-alone risk factor for residual/recurrent CIN (OR = 50.3; 95% Cl 3.8 to 663.1). Conclusions: High risk HPV DNA detection decreased substantially after CIN treatment with LLETZ, but HPV persistence was strongly correlated with residual/recurrent CIN.pt
dc.relation.ispartofTumoript_BR
dc.relation.ispartofabbreviationTumoript_BR
dc.publisher.cityRomept_BR
dc.publisher.countryItáliapt_BR
dc.publisherPensiero Scientifico Editorpt_BR
dc.date.issued2005pt_BR
dc.date.monthofcirculationMAR-APRpt_BR
dc.identifier.citationTumori. Pensiero Scientifico Editor, v. 91, n. 2, n. 188, n. 192, 2005.pt_BR
dc.language.isoenpt_BR
dc.description.volume91pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage188pt_BR
dc.description.lastpage192pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0300-8916pt_BR
dc.identifier.wosidWOS:000229787800016pt_BR
dc.date.available2014-11-14T10:13:04Z
dc.date.available2015-11-26T17:14:19Z-
dc.date.accessioned2014-11-14T10:13:04Z
dc.date.accessioned2015-11-26T17:14:19Z-
dc.description.provenanceMade available in DSpace on 2014-11-14T10:13:04Z (GMT). No. of bitstreams: 1 WOS000229787800016.pdf: 65360 bytes, checksum: eaaad96fb942e0d4e1df45831e9bfdc2 (MD5) Previous issue date: 2005en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:14:19Z (GMT). No. of bitstreams: 2 WOS000229787800016.pdf: 65360 bytes, checksum: eaaad96fb942e0d4e1df45831e9bfdc2 (MD5) WOS000229787800016.pdf.txt: 24487 bytes, checksum: e09260be063c64737799b52cc90675bb (MD5) Previous issue date: 2005en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68918pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/68918
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68918-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000229787800016.pdf63.83 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.