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Type: Artigo de periódico
Title: Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt
Author: Favaro, PMB
Medina, SD
Traina, F
Basseres, DS
Costa, FF
Saad, STO
Abstract: The very large family of Formin proteins is involved in processes such as morphogenesis, embryonic differentiation, cell polarity, and cytokinesis. A novel human gene from the Formin family, denominated human leukocyte formin gene, was cloned. The cDNA of the gene was determined to be 3959 bp long with an open reading frame of 3302 bp and computational analysis located this gene on chromosome 17, suggesting that it is composed of 27 exons. Northern blot analysis revealed a restricted expression of mRNA in the thymus, spleen, and peripheral blood leukocytes in normal human tissues. Western blot analysis demonstrated that the protein encoded by this gene is overexpressed in lymphoid malignancies; cancer cell lines and peripheral blood leukocyte from chronic lymphocytic leukemia (CLL) patients. Furthermore, the human leukocyte formin protein was observed to associate with Akt, a critical survival regulator in many different cell types. (C) 2003 Elsevier Inc. All rights reserved.
Subject: formin
human leukocyte formin
lymphoid malignancies
Country: EUA
Editor: Academic Press Inc Elsevier Science
Citation: Biochemical And Biophysical Research Communications. Academic Press Inc Elsevier Science, v. 311, n. 2, n. 365, n. 371, 2003.
Rights: fechado
Identifier DOI: 10.1016/j.bbrc.2003.10.012
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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