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Type: Artigo de periódico
Title: HPV infection in Brazilian patients with esophageal squamous cell carcinoma: Interpopulational differences, lack of correlation with surrogate markers and clinicopathological parameters
Author: Herbster, S
Ferraro, CTL
Koff, NK
Rossini, A
Kruel, CDP
Andreollo, NA
Rapozo, DCM
Blanco, TCM
de Faria, PAS
Santos, PTD
Albano, RM
Simao, TD
Pinto, LFR
Abstract: The role of HPV in esophageal squamous cell carcinoma (ESCCs) is controversial. Therefore, we determined, through different methodologies, the prevalence of HPV in 264 ESCC samples from Brazil, and correlated it with the presence of surrogate markers and clinicopathological characteristics. HPV is present in 13% of ESCC, and with a 3-fold variation between high and medium incidence areas. Most HPV positive tumors were infected with HPV16, but this was not associated with p16 expression, TP53 mutation status, patient age, amount of tobacco or alcohol consumption, or overall survival. We conclude that HPV infection may not have a role in ESCC. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Subject: Cancer
Country: Irlanda
Editor: Elsevier Ireland Ltd
Citation: Cancer Letters. Elsevier Ireland Ltd, v. 326, n. 1, n. 52, n. 58, 2012.
Rights: fechado
Identifier DOI: 10.1016/j.canlet.2012.07.018
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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