Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/68614
Type: Artigo de periódico
Title: HB LEPORE(BALTIMORE) (DELTA-50SER BETA-86ALA) IDENTIFIED BY DNA ANALYSIS IN A BRAZILIAN FAMILY
Author: MIRANDA, SRP
FIGUEIREDO, MS
KERBAUY, J
GROTTO, HZW
SAAD, STO
COSTA, FF
Abstract: Genomic DNA from two Brazilian hemoglobin (Hb) Lepore heterozygotes of Italian ancestry have been studied in order to identify the Hb Lepore type and to sequence the breakpoint region. The two genes were sequenced after PCR amplification and had the delta globin sequence up to exon 2 codon 68 while the first specific base for the beta globin gene was at codon 86 of the second exon; between the two ends, they had 51 base pairs in common with the delta and beta globin genes. These data indicate that the mutation was of the Hb Lepore(Baltimore) type. The Lepore chromosome haplotype was different from that previously described in members of a Spanish family with Hb Lepore(Baltimore). These data suggest that independent mutations have given rise to Hb Lepore(Baltimore) in different regions of the world.
Subject: DNA ANALYSIS
HAPLOTYPES
HEMOGLOBIN LEPORE
Country: Suíça
Editor: Karger
Rights: fechado
Date Issue: 1994
Appears in Collections:Unicamp - Artigos e Outros Documentos

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