Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/686
Type: Artigo de periódico
Title: T allele of-344C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension
Author: LACCHINI, Riccardo
SABHA, Maricene
COELI, Fernanda B.
FAVERO, Fabricio F.
YUGAR-TOLEDO, Juan
IZIDORO-TOLEDO, Tatiane C.
SANDRIM, Valria C.
TANUS-SANTOS, Jose E.
MELLO, Maricilda P. de
MORENO JR., Heitor
Abstract: Resistant hypertension (RH) is the maintenance of elevated blood pressure concurrent with the use of three different antihypertensive drugs, one of which is a diuretic. The Renin-Angiotensin-Aldosterone System plays a major role in volume-dependent hypertension. Therefore, its components are interesting targets for genetic association studies. This work focused on the -344 C/T polymorphism in the CYP11b2 gene, which encodes aldosterone synthase. This work evaluates the association between T allele and resistance to anti-hypertensive treatment. Genotyping analysis included 88 subjects with RH, 142 who were responsive to anti-hypertensive treatment and 110 subjects as a control group. Plasmatic concentrations of aldosterone, renin and cortisol, carotid intima-media thickness and carotid-femoral pulse wave velocity were assessed in a smaller subset of hypertensive patients. An association was found between T allele and hypertension (P < 0.005), but there was no difference in allele frequencies between both hypertensive groups. There was no difference in plasmatic parameters either, in remodeling indicators between the genotypic groups.
Subject: aldosterone
CYP11b2
pharmacogenetics
refractory hypertension
resistant hypertension
Country: Inglaterra
Editor: NATURE PUBLISHING GROUP
Rights: fechado
Identifier DOI: 10.1038/hr.2008.36
Address: http://dx.doi.org/10.1038/hr.2008.36
http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000263924000009&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
Date Issue: 2009
Appears in Collections:FCM - Artigos e Outros Documentos

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