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Type: Artigo de periódico
Title: Hard palate hyperpigmentation secondary to chronic chloroquine therapy: report of five cases
Author: de Andrade, BAB
Fonseca, FP
Pires, FR
Mesquita, ATM
Falci, SGM
Silva, ARD
Vargas, PA
Jorge, J
de Almeida, OP
Abstract: Antimalarials are commonly prescribed in medical practice for conditions such as rheumatoid arthritis, lupus erythematosus, as well as malaria. They are generally well-tolerated, but side effects, although infrequent, are well known. The antimalarial chloroquine diphosphate may be associated with a bluish-gray to black hyperpigmentation of the oral mucosa, mainly on the hard palate. In this report we described five additional cases of palate hyperpigmentation related to the chronic use of chloroquine diphosphate. Professionals must be aware of the adverse effects of antimalarials as chloroquine diphosphate in order to make the correct diagnosis and appropriate management of the patient. Early diagnosis of oral pigmentation by antimalarials may be of great relevance, because it might be an early sign of ocular involvement, and therefore it may be helpful to prevent further complications of antimalarial therapy for the patient.
Subject: adverse reaction
hard palate
Country: EUA
Editor: Wiley-blackwell
Citation: Journal Of Cutaneous Pathology. Wiley-blackwell, v. 40, n. 9, n. 833, n. 838, 2013.
Rights: fechado
Identifier DOI: 10.1111/cup.12182
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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