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Type: Artigo de periódico
Title: Haptoglobin polymorphism and diabetic retinopathy in Brazilian patients
Author: Wobeto, VPA
Rosim, ET
Melo, MB
Calliari, LEP
Sonati, MD
Abstract: Haptoglobin (Hp) is an acute phase protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2) show distinct efficiencies in these activities and have been associated with susceptibility and outcome in several diseases, including diabetes mellitus (DM). It has been suggested that Hp polymorphism may influence the development of retinopathy, an important microvascular complication in DM. In order to investigate this association in a Brazilian population, we determined the Hp genotypes of 317 diabetic patients with at least 10 years of disease. The patients were classified as DM-type 1 and 2, with and without diabetic retinopathy (DR). The Hp genotype frequencies of the different patient groups and of a control group consisting of 142 healthy individuals who had previously been studied were compared. No significant differences were observed for the three Hp genotypes. Hemoglobin Alc levels, systolic blood pressure (SBP), diastolic blood pressure (DBP) and duration of diabetes, which are potential risk factors for DR, were also compared. Again no significant differences were observed for the three Hp genotypes. Thus, we conclude that this polymorphism is not associated with the presence of DR in the Brazilian population studied here. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
Subject: haptoglobin genotypes
diabetes mellitus
diabetic retinopathy
genetic polymorphisms
Brazilian population
Country: Irlanda
Editor: Elsevier Ireland Ltd
Citation: Diabetes Research And Clinical Practice. Elsevier Ireland Ltd, v. 77, n. 3, n. 385, n. 388, 2007.
Rights: fechado
Identifier DOI: 10.1016/j.diabres.2006.12.018
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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