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Type: Artigo de periódico
Title: Haptoglobin genotypes in Chagas' disease
Author: Jorge, SEDC
Abreu, CF
Guariento, ME
Sonati, MD
Abstract: Objectives: To investigate the existence of an association between haptoglobin (Hp) genotypes and the severity of heart complications in Chagas' disease. Design and methods: Hp genotyping was performed by PCR in 107 Brazilian patients sub-classified in asymptomatic, with mild heart disease and with severe heart disease. Results: Multiple logistic regression (R(2) = 24%) indicated that patients with the Hp1-1 genotype have lower probability of developing the severe heart complications. Conclusion: The Hp polymorphism may influence the clinical evolution of Chagas' disease. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Subject: Cardiomyopathies
Chagas' disease
Trypanosoma cruzi
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Clinical Biochemistry. Pergamon-elsevier Science Ltd, v. 43, n. 3, n. 314, n. 316, 2010.
Rights: fechado
Identifier DOI: 10.1016/j.clinbiochem.2009.09.020
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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