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|Type:||Artigo de periódico|
|Title:||Green spectrophotometric method for the quantitative analysis of vancomycin in pharmaceuticals and comparison with HPLC|
|Abstract:||A spectrophotometric method for the determination of vancomycin base, (VCM), and vancomycin hydrochloride, (HVCM), based on the reaction with copper (II) ions, is presented. The obtained detection limit is about 4.5 x 10(-5) mol L-1. The working analytical range falls between 1.0 x 10(-3) mol L-1 and 1.0 x 10(-2) mol L-1. Recovery studies in presence of excipients were performed. The recovery results were compared with HPLC. For HVCM the proposed method presented similar recovery to that of HPLC, 100.4% vs. 100.2%, but better precision, 1.9% vs. 6.1%. In the VCM case the recovery is quite better, 100.5% vs. 89.6%, with a little smaller precision, 2.1% vs. 1.3%.|
|Editor:||Taylor & Francis Inc|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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