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Type: Artigo de periódico
Title: Green spectrophotometric method for the quantitative analysis of vancomycin in pharmaceuticals and comparison with HPLC
Author: Rodrigues, A
Vila, MMDC
Tubino, M
Abstract: A spectrophotometric method for the determination of vancomycin base, (VCM), and vancomycin hydrochloride, (HVCM), based on the reaction with copper (II) ions, is presented. The obtained detection limit is about 4.5 x 10(-5) mol L-1. The working analytical range falls between 1.0 x 10(-3) mol L-1 and 1.0 x 10(-2) mol L-1. Recovery studies in presence of excipients were performed. The recovery results were compared with HPLC. For HVCM the proposed method presented similar recovery to that of HPLC, 100.4% vs. 100.2%, but better precision, 1.9% vs. 6.1%. In the VCM case the recovery is quite better, 100.5% vs. 89.6%, with a little smaller precision, 2.1% vs. 1.3%.
Subject: vancomycin
green method
Country: EUA
Editor: Taylor & Francis Inc
Citation: Analytical Letters. Taylor & Francis Inc, v. 41, n. 5, n. 822, n. 836, 2008.
Rights: fechado
Identifier DOI: 10.1080/00032710801935103
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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