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Type: Artigo de periódico
Title: Highly diastereoselective total synthesis of the anti-tumoral agent (+/-)-Spisulosine (ES285) from a Morita-Baylis-Hillman adduct
Author: Amarante, GW
Cavallaro, M
Coelho, F
Abstract: We disclose herein a new approach for the highly diastereoselective total synthesis of the anti-tumoral agent (+/-)-Spisulosine. The synthesis was accomplished in seven steps with an overall yield of 10%. The key step involves the transformation of a Morita-Baylis-Hillman into an acyloin, which was subsequently used as substrate in a highly diastereoselective reductive amination reaction. (C) 2010 Elsevier Ltd. All rights reserved.
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 51, n. 19, n. 2597, n. 2599, 2010.
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2010.02.169
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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